The tie is finely poised after the two teams drew 1-1 in Spain in the first leg. Dusan Vlahovic put Juventus ahead in the first minute, but Villarreal equalised in the second half through Dani Parejo.
Juventus have been knocked out at the Round of 16 stage in the past two seasons, so they will be determined to avoid suffering the same fate again.
Villarreal, meanwhile, won the Europa League last season and are now looking to progress in the Champions League.
How to watch Juventus vs. Villarreal
Date: Wed. , March 16 Time: 4 p. m. ET USA TV channel: Univision, TUDN USA streaming: fuboTV, Paramount+ Canada TV streaming: DAZN
In the USA, the game will be broadcast on Univision and TUDN, with both channels streamed on fuboTV, which is available to new users on a free trial. The match will also be streamed in English on Paramount+.
Champions League matches are available exclusively live and on demand on DAZN.
Juventus vs. Villarreal predicted lineups
Giorgio Chiellini and Paulo Dybala could return for Juventus, while Dusan Vlahovic is set to return to the starting lineup. Denis Zakaria, Leonardo Bonucci, Weston McKennie, and Federico Chiesa remain out.
Juventus predicted lineup: Szczesny (GK) - Danilo, De Ligt, Chiellini, Alex Sandro - Arthur, Locatelli, Rabiot - Cuadrado, Vlahovic, Morata
For Villarreal, Raul Albiol could be available despite having been taken off against Celta Vigo. Etienne Capoue, Gerard Moreno, and Juan Foyth are doubtful for Unai Emery’s side, and three players - Paco Alcacer, Alberto Moreno and Ruben Pena - are definitely out.
Villarreal predicted lineup: Rulli (GK) - Aurier, Albiol, Torres, Pedraza, Iborra, Pedraza - Chukwueze, Lo Celso, Trigueros - Danjuma
Juventus vs. Villarreal betting odds and pick
Odds courtesy of DraftKings
Juventus’ Vlahovic could have an important part to play in determining the outcome of this tie, and the Serbian striker seems a good choice to be the first goal scorer.
It is a difficult game to call, but Juventus appear more likely to progress.
Pick: Vlahovic to score first (+350)
Moneyline: Juventus -105 / Draw +250 / Villarreal +330 Spread: Juventus -0. 5 (-105) / Villarreal 0. 5 (-110) Over/Under 2. 5 Goals: Over +110 / Under -135 Both Teams to Score: Yes -120 / No -110
